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Senior Scientist Integrated Bioanalysis - Discovery Bioanalysis
Location:
Gaithersburg, MD
Description:
Senior Scientist Integrated Bioanalysis - Discovery Bioanalysis Introduction to role: Join our Integrated Bioanalysis (iBA) Global Team, where you will be supporting the growing portfolio of ADCs and other complex biotherapeutics by applying advanced bioanalytical techniques with LCMS-focus. This is an important technical and scientific role responsible for strengthening technical capabilities to design and implement robust bioanalytical strategies. You will have the opportunity to have an immediate and lasting impact on our diverse pipeline. The Integrated Bioanalysis team within Clinical Pharmacology and Safety Sciences provides broad discovery, preclinical, and clinical support across all therapeutic areas enabling pipeline delivery, decision making, innovation and advancement to improve the lives of patients through life-changing medicines.At AstraZeneca , we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe!We are seeking a highly skilled and motivated Senior Scientist to join our Group within Integrated Bioanalysis. The position will take a lead role in the lab designing and interpreting mass spectrometry-based approaches for advancing our drug pipeline and working as the group representative in multidiscipline drug development teams.The position is in our Integrated Bioanalysis Department which part of the Clinical Pharmacology and Safety Science Group and is responsible for providing high quality, decision driving data using a variety of platform technologies. Our team primarily focusses on pre-GLP bioanalyses along with exploratory biomarkers assessments all therapeutic areas. We have a diverse array of scientists working across many technologies to ensure delivery of critical assays, and data analysis that drive go/no go decisions and ensure the right combination of medicines get to the right patient, in the right dose, at the right time. What you'll do This position will lead mass spectrometry pharmacokinetics and in the laboratory and through outsourcing to better understand drug actions and their association with pharmacodynamics and clinical response.Your principle responsibility will be in the lab, designing, developing, and interpreting assays to support drug and ADC program transition through lead candidate selection and into clinical trials.You will be expected to represent the department on multidiscipline drug development teams, thus ability to support other technologies in the lab, especially ligand binding and cell-based functional assays will be a benefit.You will report into a head of Discovery LC-MS in Gaithersburg and be expected to take a lead role in pushing the boundaries of what is possible for mass spectrometry based bioanalyses in determining lead drug candidates and enabling global clinical trials. Essential Requirements: PhD in Analytical Chemistry, Biochemistry or related discipline preferred. Must possess relevant experience in biotherapeutics analysis, 1-3 yrsMaster's degree in Analytical Chemistry, Biochemistry or related discipline required with at least 5 years of experience post-Masters. Must possess relevant industry experience. A highly motivated Ph.D. Scientist (industry experience perferred) coming from projects that required advanced mass spectrometry assay development and data interpretation skills.Experience designing, optimizing, and analyzing multiple reaction monitoring (MRM) based assays for quantifications of ADC, payload, metabolites.Experience separating peptides and small molecules by liquid chromatography.Experience with high-resolution mass spectrometry platforms.A high level of independence and with an ability to develop hypotheses and execute analysis plans for pharmacokinetics, pharmacodynamics and proteomics biomarker data.Attention to detail, good communication, and collaboration skills. Outstanding record keeping skills are critical for success.An ability to think and act creatively- independently, and within collaborations. Desirable for the role Experience with advanced data analysis tools for analyzing and visualizing intact protein MS data.Operational experience with broader immunoassays e.g. ELISA, multiplex assays, Elispots etc.Knowledge of GxP regulations Why AstraZeneca? Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference. We have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. It's our combination of curiosity and courage that drives us, inspired by the possibility of doing things that have never been done before. Empowered to step up, we free ourselves from fear of failure to dig deep into the biology of complex diseases and make bold decisions. Celebrating our successes and failures along the way.Ready to make a difference?Apply now and join us in our mission to improve lives through life-changing medicines! Date Posted 13-Jun-2024 Closing Date 29-Jun-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
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More About this Listing: Senior Scientist Integrated Bioanalysis - Discovery Bioanalysis
Senior Scientist Integrated Bioanalysis - Discovery Bioanalysis is a Science & Pharmaceutical Scientist Job at Astrazeneca located in Gaithersburg MD. Find other listings like Senior Scientist Integrated Bioanalysis - Discovery Bioanalysis by searching Oodle for Science & Pharmaceutical Scientist Jobs.
Senior Scientist Integrated Bioanalysis - Discovery Bioanalysis is a Science & Pharmaceutical Scientist Job at Astrazeneca located in Gaithersburg MD. Find other listings like Senior Scientist Integrated Bioanalysis - Discovery Bioanalysis by searching Oodle for Science & Pharmaceutical Scientist Jobs.