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Investigator, Modelling and Simulation
Location:
Collegeville, PA
Description:
The Investigator, Modelling and Simulation, will be part of a team developing advanced modelling approaches to accelerate development, increase fundamental understanding, improve risk assessment, and deliver more robust processes for sterile drug products and large molecule drug substance. This includes the application of mechanistic modelling (particularly System Modelling), data driven modelling, and hybrid methodologies in process design, control strategy definition, and advanced process monitoring & control. This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include the following: As part of matrix project teams, develop and deploy mechanistic, data driven, and hybrid modelling solutions for sterile drug products and large molecule drug substance. Use engineering, chemical, biological, and materials science knowledge to postulate mechanisms for physiochemical processes and develop or modify existing mathematical models to describes those mechanisms. Design experimentation and analysis required to develop and verify system models. Develop product performance models. Build systems-based understanding of sterile drug products integrating materials science understanding, process, and product performance models. Translate mathematical models to computer models using software platforms (e.g., gPROMS) or by writing custom programs. Understand the requirements to develop model-based soft sensors and model predictive control. Work closely with the Quality, Regulatory and other experts to integrate process modelling approaches into QbD process development for small molecule drug substance. Work closely with Statistical Sciences to develop the best in-silico experimental design and to engage them to assess model uncertainty and model predictive confidence limits. Stay current with new modelling techniques through publications, conferences and academic and precompetitive collaborations. Track progress against deliverables and maintain a communication plan with stakeholders and partners across departments. Advocate and comply with GMP requirements for recording experiments and associated data, and writing reports, including scientific review and data checking. Comply with the requirements of Quality, Safety, and GSK policies and procedures and ensure that GSK intellectual property is protected. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Ph.D. in Chemical Engineering, Chemistry, Materials Sciences with an emphasis on development and implementation of mechanistic mathematical models and / or data driven modelling approaches for sterile drug products or large molecule drug substance operations. Experience translating mathematical models into computer programs using MATLAB, Python, or similar software tools. Preferred Qualifications: If you have the following characteristics, it would be a plus: An understanding of statistical science and related software tools that enable sound experimental design and interpretation of models. 2+ years of previous industry or post-doctoral experience Publications in peer reviewed journals. Experience in system modelling and platforms such as gPROMs. Understanding of in vitro and in vivo product performance modelling. Prior experience working on model-based soft sensors and development of digital twins. Good interpersonal, organizational and communications skills. *LI-GSKPlease visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-XXXX (US Toll Free) or +1 801 567 XXXX (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.PDN-9bc76a64-a7d6-4ff3-b249-260056a5ee1b
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Investigator, Modelling and Simulation is a Other Jobs Investigator Job at GSK located in Collegeville PA. Find other listings like Investigator, Modelling and Simulation by searching Oodle for Other Jobs Investigator Jobs.
Investigator, Modelling and Simulation is a Other Jobs Investigator Job at GSK located in Collegeville PA. Find other listings like Investigator, Modelling and Simulation by searching Oodle for Other Jobs Investigator Jobs.